South Africa sent Australia to its first-ever 5-0 whitewash in a one-day series, winning the final game at Newlands by 31 runs on Wednesday.
South Africa, 4-0 up in five-match series, is eyeing a historic whitewash against the world No. 1 ODI side.
South Africa secured a fourth successive one-day international victory over Australia as captain Faf du Plessis top scored with 69 runs in a six-wicket win on Sunday.
David Miller blasted an unbeaten century as South Africa chased down a massive target of 372 in the third one-dayer against Australia at Kingsmead on Wednesday to clinch the series.
Hosts cruise to a 142-run win over Australia after the South African captain scored 111.
Young Proteas wicket-keeper batsman powers record-breaking 178 to make light work of 295 target.
With several of Australia's quicks unavailable due to injury or rest, South Africa has the edge going into first ODI.
Steve Smith and Usman Khawaja propelled Australia to a nine-wicket victory over Ireland in one-off ODI at Willowmoore Park on Tuesday.
Australia will face Ireland in one-off ODI on Tuesday before they faces hosts South Africa in a five-match series.
Temba Bavuma starred for the hosts with a century on debut as South Africa beat Ireland by 206-runs in one-off ODI at Benoni.