Hardik Pandya, Shardul Thakur, Axar Patel left out; Deepak Chahar and Siddharth Kaul also include.
Sherman Lewis, the right-arm fast bowler from Windward Islands, has been called up for their tour of India in October.
Bhuvneshwar Kumar (3/15) and Kedar Jadhav (3/23) bowled out Pakistan on 162 and chase easily with 21 overs remaining.
Olly Stone named in England ODI squad as cover for Liam Plunkett wedding clash.
Hardik Pandya stretchered off the field after suffering acute lower back injury.
After winning their opening games against Hong Kong, India and Pakistan will take on each other on Wednesday.
From 174-0, Hong Kong lost their way and huffed and puffed past the 250-run mark, eventually India won by 26 runs.
Hong Kong will look to raise their game against defending champions India in Dubai on Tuesday.
Afghanistan knocked five-time champions Sri Lanka out of the Asia Cup with a 91-run win here Monday.
Pakistan starts the tournament with a thumping 8 wicket win over Hong Kong in Dubai on Sunday.